2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140836
    Boc-NH-PEG4-azide 940951-99-5
    Boc-NH-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Boc-NH-PEG4-azide
  • HY-140207
    Amino-PEG36-alcohol 2718868-96-1
    Amino-PEG36-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG36-alcohol
  • HY-140748
    BnO-PEG4-Boc 1807503-89-4 98.0%
    BnO-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    BnO-PEG4-Boc
  • HY-138402
    Boc-NH-PEG15-C1-acid
    Boc-NH-PEG15-C1-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG15-C1-acid
  • HY-141163
    TCO-PEG24-acid
    TCO-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    TCO-PEG24-acid
  • HY-141076
    N-(m-PEG4)-N'-(PEG3-Mal)-Cy5 2839527-02-3
    N-(m-PEG4)-N'-(PEG3-Mal)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-(m-PEG4)-N'-(PEG3-Mal)-Cy5
  • HY-130293
    Propargyl-PEG4-CH2CH2-Boc 1245823-50-0
    Propargyl-PEG4-CH2CH2-Boc is a non-cleavable ADC linker that can be used to synthesize ADC inhibitors of Galectin-3. Propargyl-PEG4-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-CH2CH2-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-CH2CH2-Boc
  • HY-170825
    (trans-4-Ethynylcyclohexyl)methyl methanesulfonate 1639795-23-5
    (trans-4-Ethynylcyclohexyl)methyl methanesulfonate is the linker that can be used for synthesis of PROTAC degrader SMD-3236 (HY-170824).
    (trans-4-Ethynylcyclohexyl)methyl methanesulfonate
  • HY-140871
    N-(Boc-PEG3)-N-bis(PEG3-azide) 2182602-15-7
    N-(Boc-PEG3)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Boc-PEG3)-N-bis(PEG3-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Boc-PEG3)-N-bis(PEG3-azide)
  • HY-132042
    Bromo-PEG2-MS 1935075-34-5
    Bromo-PEG2-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG2-MS
  • HY-171559
    TCO-PEG5-NHS ester 2714310-77-5
    TCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG5-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    TCO-PEG5-NHS ester
  • HY-138388
    Azido-PEG4-formylhydrazine-Boc
    Azido-PEG4-formylhydrazine-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-formylhydrazine-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-formylhydrazine-Boc
  • HY-140000
    Methylamino-PEG1-acid 1367918-21-5
    Methylamino-PEG1-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methylamino-PEG1-acid
  • HY-134737
    Boc-NH-PEG1-C5-OH
    Boc-NH-PEG1-C5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG1-C5-OH
  • HY-133342
    H2N-PEG8-Hydrazide
    H2N-PEG8-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    H2N-PEG8-Hydrazide
  • HY-132063
    MS-PEG3-dodecyl 2148295-99-0
    MS-PEG3-dodecyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    MS-PEG3-dodecyl
  • HY-130641
    Br-C10-methyl ester 6287-90-7
    Br-C10-methyl ester is a PROTAC linker, which refers to the alkyl/ether composition. Br-C10-methyl ester is used in the synthesis of a series of PROTACs (MS432).  PROTACs contain two different ligands connected by a linker; one is the VHL ligand portion and the other is for the target protein.
    Br-C10-methyl ester
  • HY-141227
    THP-PEG11-OH
    THP-PEG11-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG11-OH
  • HY-140400
    Aminooxy-PEG8-methane 2055024-52-5
    Aminooxy-PEG8-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Aminooxy-PEG8-methane
  • HY-130443
    Cbz-NH-PEG6-C2-acid 1334177-80-8
    Cbz-NH-PEG6-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cbz-NH-PEG6-C2-acid
PROTAC Linkers Isoform Comparison

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